Review: Natural Compounds from Terrestrial with Antimalarial Activity

  • Jefry Presson Timor University.
Keywords: Antimalaria, Plasmodium falciparum, Terrestrial, Natural Product


Malaria is still a major public health problem that urgently needs some new treatments due to the development of resistance by the most dangerous parasitic species, Plasmodium falciparum. The parasite responsible to malaria which claimed as the most lethal disease are endless handled due to increasing prevalence. Based on World Malarial Report in 2015 by WHO, about 214 million cases of malaria and 438,000 death occurred among them. Moreover, discontinue of artemisinin because of its resistance in Southeast Asia indicate that the discovery of new antimalarial drug is highly important. This review present recent research and development progress in antimalarial drug discovery from natural sources especially on terrestrial.


Download data is not yet available.


Angerhofer, C.K., Guinaudeau, H., Wongpanich, V., Pezzuto, J.M. & Cordell, G.A. 1999. Antiplasmodial and Cytotoxic Activity of Natural Bisbenzylisoquinoline Alkaloids. Journal of Natural Products, 62(1): 59–66.

Argotte-Ramos, R., Ramírez-Avila, G., Rodríguez-Gutiérrez, M. del C., Ovilla-Muñoz, M., Lanz-Mendoza, H.,
Rodríguez, M.H., González-Cortazar, M. & Alvarez, L. 2006. Antimalarial 4-phenylcoumarins from the stem bark of Hintonia latiflora. Journal of natural products, 69(10): 1442–1444.

Bickii, J., Njifutie, N., Foyere, J.A., Basco, L.K. & Ringwald, P. 2000. In vitro antimalarial activity of limonoids from Khaya grandifoliola CDC (Meliaceae). Journal of Ethnopharmacology, 69(1): 27–33.

Bray, D.H., Warhurst, D.C., Connolly, J.D., O’Neill, M.J. & Phillipson, J.D. 1990. Plants as sources of antimalarial drugs. Part 7. Activity of some species of Meliaceae plants and their constituent limonoids. Phytotherapy Research, 4(1): 29–35.

Bringmann, G., Hamm, A., Günther, C., Michel, M., Brun, R. & Mudogo, V. 2000a. Ancistroealaines A and B, two new bioactive naphthylisoquinolines, and related naphthoic acids from Ancistrocladus ealaensis. Journal of natural products, 63(11): 1465–1470.

Bringmann, G., Ochse, M., Zotz, G., Peters, K., Peters, E.-M., Brun, R. & Schlauer, J. 2000b. 6-Hydroxyluteolin-7-O-(1′′-α-rhamnoside) from Vriesea sanguinolenta Cogn. and Marchal (Bromeliaceae). Phytochemistry, 53(8): 965–969.

Chanphen, R., Thebtaranonth, Y., Wanauppathamkul, S. & Yuthavong, Y. 1998. Antimalarial principles from Artemisia indica. Journal of natural products, 61(9): 1146–1147.

Chen, M., Theander, T.G., Christensen, S.B., Hviid, L., Zhai, L. & Kharazmi, A. 1994. Licochalcone A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection. Antimicrobial agents and chemotherapy, 38(7): 1470–1475.

Darkin-Rattray, S.J., Gurnett, A.M., Myers, R.W., Dulski, P.M., Crumley, T.M. & Allocco, J.J. n.d. 693 Cannova C, Meinke PT, Colletti SL, Bednarek MA, Singh SB, Goetz MA, 694 Dombrowski AW, Polishook JD, Schmatz DM. 1996. Apicidin: a novel antiprotozoal 695 agent that inhibits parasite histone deacetylase. Proc Natl Acad Sci USA, 93: 13143–13696.

Elford, B.C. 1986. L-Glutamine influx in malaria-infected erythrocytes: a target for antimalarials? Parasitology Today, 2(11): 309–312.

Figueiredo, J.N., Räz, B. & Séquin, U. 1998. Novel quinone methides from Salacia kraussii with in vitro antimalarial activity. Journal of Natural Products, 61(6): 718–723.

François, G., Passreiter, C.M., Woerdenbag, H.J. & Van Looveren, M. 1996. Antiplasmodial activities and cytotoxic effects of aqueous extracts and sesquiterpene lactones from Neurolaena lobata. Planta medica, 62(02): 126–129.

Frédérich, M., Cristino, A., Choi, Y.H., Verpoorte, R., Tits, M., Angenot, L., Prost, E., Nuzillard, J.-M. & Zèches-Hanrot, M. 2004. Chrysopentamine, an antiplasmodial anhydronium base from Strychnos usambarensis leaves. Planta medica, 70(1): 72–76.

Frederich, M., De Pauw, M.-C., Llabres, G., Tits, M., Hayette, M.-P., Brandt, V., Penelle, J., De Mol, P. & Angenot, L. 2000. New antimalarial and cytotoxic sungucine derivatives from Strychnos icaja roots. Planta medica, 66(03): 262–269.

Ghosh, J.K., Shaool, D., Guillaud, P., Cicéron, L., Mazier, D., Kustanovich, I., Shai, Y. & Mor, A. 1997. Selective Cytotoxicity of Dermaseptin S3 toward IntraerythrocyticPlasmodium falciparum and the Underlying Molecular Basis. Journal of Biological Chemistry, 272(50): 31609–31616.

Hallock, Y.F., Cardellina, J.H., Schäffer, M., Bringmann, G., François, G. & Boyd, M.R. 1998. Korundamine A, a novel HIV-inhibitory and antimalarial “hybrid” naphthylisoquinoline alkaloid heterodimer from Ancistrocladus korupensis. Bioorganic & Medicinal Chemistry Letters, 8(13): 1729–1734.

Hallock, Y.F., Manfredi, K.P., Dai, J.-R., Cardellina, J.H., Gulakowski, R.J., McMahon, J.B., Schäffer, M., Stahl, M.,
Gulden, K.-P., Bringmann, G., François, G. & Boyd, M.R. 1997. Michellamines D−F, New HIV-Inhibitory Dimeric Naphthylisoquinoline Alkaloids, and Korupensamine E, a New Antimalarial Monomer, from Ancistrocladus korupensis. Journal of Natural Products, 60(7): 677–683.

Hay, A.-E., Ioset, J.-R., Ahua, K.M., Diallo, D., Brun, R. & Hostettmann, K. 2007. Limonoid orthoacetates and antiprotozoal compounds from the roots of Pseudocedrela kotschyi. Journal of natural products, 70(1): 9–13.

Ichino, C., Kiyohara, H., Soonthornchareonnon, N., Chuakul, W., Ishiyama, A., Sekiguchi, H., Namatame, M., Otoguro, K., Omura, S. & Yamada, H. 2006. Antimalarial activity of biflavonoids from Ochna integerrima. Planta medica, 72(07): 611–614.

Jenett-Siems, K., Siems, K., Jakupovic, J., Solis, P.N., Gupta, M.P., Mockenhaupt, F.P., Bienzle, U. & Eich, E. 2000. Sipandinolide: a butenolide including a novel type of carbon skeleton from Siparuna andina. Planta medica, 66(04): 384–385.

Karioti, A., Skaltsa, H., Zhang, X., Tonge, P.J., Perozzo, R., Kaiser, M., Franzblau, S.G. & Tasdemir, D. 2008. Inhibiting enoyl-ACP reductase (FabI) across pathogenic microorganisms by linear sesquiterpene lactones from Anthemis auriculata. Phytomedicine, 15(12): 1125–1129.

Kenmogne, M., Prost, E., Harakat, D., Jacquier, M.-J., Frédérich, M., Sondengam, L.B., Zeches, M. & Waffo-Téguo, P. 2006. Five labdane diterpenoids from the seeds of Aframomum zambesiacum. Phytochemistry, 67(5): 433–438.

Kirmizibekmez, H., Calis, I., Perozzo, R., Brun, R., Donmez, A.A., Linden, A., Rudi, P. & Tasdemir, D. 2004. Inhibiting activities of the secondary metabolites of Phlomis brunneogaleata against parasitic protozoa and plasmodial enoyl-ACP reductase, a crucial enzyme in fatty acid biosynthesis. Planta medica, 70(8): 711–717.

Klayman, D.L. 1985. Qinghaosu (artemisinin): an antimalarial drug from China. Science, 228(4703): 1049 LP-1055.

Köhler, I., Jenett-Siems, K., Mockenhaupt, F.P., Siems, K., Jakupovic, J., González, J.C., Marco, A., Hernández, R., Ibarra, W.A. & Berendsohn, U.G. 2001. In vitro antiplasmodial activity of 4-phenylcoumarins from Exostema mexicanum. Planta medica, 67(01): 89–91.

Kraft, C., Jenett-Siems, K., Siems, K., Gupta, M.P., Bienzle, U. & Eich, E. 2000. Antiplasmodial activity of isoflavones from Andira inermis. Journal of ethnopharmacology, 73(1–2): 131–135.

Krief, S., Martin, M.-T., Grellier, P., Kasenene, J. & Sévenet, T. 2004. Novel antimalarial compounds isolated in a survey of self-medicative behavior of wild chimpanzees in Uganda. Antimicrobial agents and chemotherapy, 48(8): 3196–3199.

Kuo, P.-C., Damu, A.G., Lee, K.-H. & Wu, T.-S. 2004. Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia. Bioorganic & medicinal chemistry, 12(3): 537–544.

Likhitwitayawuid, K., Phadungcharoen, T. & Krungkrai, J. 1998. Antimalarial xanthones from Garcinia cowa. Planta medica, 64(01): 70–72.

Limmatvapirat, C., Sirisopanaporn, S. & Kittakoop, P. 2004. Antitubercular and antiplasmodial constituents of Abrus precatorius. Planta medica, 70(3): 276–278.

Ma, C., Zhang, H.J., Tan, G.T., Hung, N. Van, Cuong, N.M., Soejarto, D.D. & Fong, H.H.S. 2006. Antimalarial compounds from Grewia bilamellata. Journal of natural products, 69(3): 346–350.

Mambu, L., Grellier, P., Florent, L., Joyeau, R., Ramanitrahasimbola, D., Rasoanaivo, P. & Frappier, F. 2006. Clerodane and labdane diterpenoids from Nuxia sphaerocephala. Phytochemistry, 67(5): 444–451.

Mambu, L., Martin, M.-T., Razafimahefa, D., Ramanitrahasimbola, D., Rasoanaivo, P. & Frappier, F. 2000. Spectral characterisation and antiplasmodial activity of bisbenzylisoquinolines from Isolona ghesquiereina. Planta medica, 66(06): 537–540.

Mbwambo, Z.H., Kapingu, M.C., Moshi, M.J., Machumi, F., Apers, S., Cos, P., Ferreira, D., Marais, J.P.J., Vanden Berghe, D. & Maes, L. 2006. Antiparasitic activity of some xanthones and biflavonoids from the root bark of Garcinia livingstonei. Journal of natural products, 69(3): 369–372.

Muhammad, I., Bedir, E., Khan, S.I., Tekwani, B.L., Khan, I.A., Takamatsu, S., Pelletier, J. & Walker, L.A. 2004. A New Antimalarial Quassinoid from Simaba o rinocensis. Journal of Natural Products, 67(5): 772–777.

Nilanonta, C., Isaka, M., Kittakoop, P., Palittapongarnpim, P., Kamchonwongpaisan, S., Pittayakhajonwut, D., Tanticharoen, M. & Thebtaranonth, Y. 2000. Antimycobacterial and antiplasmodial cyclodepsipeptides from the insect pathogenic fungus Paecilomyces tenuipes BCC 1614. Planta medica, 66(08): 756–758.

Nunome, S., Ishiyama, A., Kobayashi, M., Otoguro, K., Kiyohara, H., Yamada, H. & Omura, S. 2004. In vitro antimalarial activity of biflavonoids from Wikstroemia indica. Planta medica, 70(01): 76–78.

Oketch-Rabah, H.A., Dossaji, S.F., Christensen, S.B., Frydenvang, K., Lemmich, E., Cornett, C., Olsen, C.E., Chen, M., Kharazmi, A. & Theander, T. 1997. Antiprotozoal compounds from Asparagus africanus. Journal of natural products, 60(10): 1017–1022.

Okunade, A.L., Bikoff, R.E., Casper, S.J., Oksman, A., Goldberg, D.E. & Lewis, W.H. 2003. Antiplasmodial activity of extracts and quassinoids isolated from seedlings of Ailanthus altissima (Simaroubaceae). Phytotherapy Research, 17(6): 675–677.

Paulo, A., Gomes, E.T., Steele, J., Warhurst, D.C. & Houghton, P.J. 2000. Antiplasmodial activity of Cryptolepis sanguinolenta alkaloids from leaves and roots. Planta Medica, 66(1): 30–34.

del Rayo Camacho, M., Mata, R., Castaneda, P., Kirby, G.C., Warhurst, D.C., Croft, S.L. & Phillipson, J.D. 2000. Bioactive compounds from Celaenodendron mexicanum. Planta medica, 66(05): 463–468.

Riel, M.A., Kyle, D.E. & Milhous, W.K. 2002. Efficacy of scopadulcic acid A against Plasmodium falciparum in vitro. Journal of natural products, 65(4): 614–615.

Rochanakij, S., Thebtaranonth, Y., Yenjai, C. & Yuthavong, Y. 1985. Nimbolide, a constituent of Azadirachta indica, inhibits Plasmodium falciparum in culture. The Southeast Asian journal of tropical medicine and public health, 16(1): 66–72.

Saewan, N., Sutherland, J.D. & Chantrapromma, K. 2006. Antimalarial tetranortriterpenoids from the seeds of Lansium domesticum Corr. Phytochemistry, 67(20): 2288–2293.

Sawadjoon, S., Kittakoop, P., Isaka, M., Kirtikara, K., Madla, S. & Thebtaranonth, Y. 2004. Antiviral and antiplasmodial spirodihydrobenzofuran terpenes from the fungus Stachybotrys nephrospora. Planta medica, 70(11): 1085–1087.

Sharma, S.K., Parasuraman, P., Kumar, G., Surolia, N. & Surolia, A. 2007. Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR). Journal of medicinal chemistry, 50(4): 765–775.

Silva, L.F.R. e, Lima, E.S., de Vasconcellos, M.C., Aranha, E.S.P., Costa, D.S., Mustafa, E.V., de Morais, S.K.R., Alecrim, M. das G.C., Nunomura, S.M., Struwe, L., de Andrade-Neto, V.F. & Pohlit, A.M. 2013. In vitro and in vivo antimalarial activity and cytotoxicity of extracts, fractions and a substance isolated from the Amazonian plant Tachia grandiflora (Gentianaceae). Memórias do Instituto Oswaldo Cruz, 108(4): 501–507.

Snow, R.W., Guerra, C.A., Noor, A.M., Myint, H.Y. & Hay, S.I. 2005. The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature, 434(7030): 214–217.

Tansuwan, S., Pornpakakul, S., Roengsumran, S., Petsom, A., Muangsin, N., Sihanonta, P. & Chaichit, N. 2007. Antimalarial benzoquinones from an endophytic fungus, Xylaria sp. Journal of natural products, 70(10): 1620–1623.

Tasdemir, D., Güner, N.D., Perozzo, R., Brun, R., Dönmez, A.A., Çalıs, I. & Rüedi, P. 2005. Anti-protozoal and plasmodial FabI enzyme inhibiting metabolites of Scrophularia lepidota roots. Phytochemistry, 66(3): 355–362.

Thiem, D.A., Sneden, A.T., Khan, S.I. & Tekwani, B.L. 2005. Bisnortriterpenes from Salacia m adagascariensis. Journal of natural products, 68(2): 251–254.

Torres-Mendoza, D., González, J., Ortega-Barría, E., Heller, M. V, Capson, T.L., McPhail, K., Gerwick, W.H. & Cubilla-Rios, L. 2006. Weakly Antimalarial Flavonol Arabinofuranosides from Calycolpus w arszewiczianus. Journal of natural products, 69(5): 826–828.

Traore, F., Faure, R., Ollivier, E., Gasquet, M., Azas, N., Debrauwer, L., Keita, A., Timon-David, P. & Balansard, G. 2000. Structure and antiprotozoal activity of triterpenoid saponins from Glinus oppositifolius. Planta Medica, 66(04): 368–371.

Uys, A.C.U., Malan, S.F., van Dyk, S. & van Zyl, R.L. 2002. Antimalarial compounds from Parinari capensis. Bioorganic & medicinal chemistry letters, 12(16): 2167–2169.

Wilairatana, P., Krudsood, S., Treeprasertsuk, S., Chalermrut, K. & Looareesuwan, S. 2002. The Future Outlook of Antimalarial Drugs and Recent Work on the Treatment of Malaria. Archives of Medical Research, 33(4): 416–421.

Wright, C.W. 2005. Plant Derived Antimalarial Agents: New Leads and Challenges. Phytochemistry Reviews, 4(1): 55–61.

Yenesew, A., Induli, M., Derese, S., Midiwo, J.O., Heydenreich, M., Peter, M.G., Akala, H., Wangui, J., Liyala, P. & Waters, N.C. 2004. Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica. Phytochemistry, 65(22): 3029–3032.
How to Cite
Presson, J. (2018). Review: Natural Compounds from Terrestrial with Antimalarial Activity. Jurnal Saintek Lahan Kering, 1(2), 31-35.
Review article